Protein

V-set domain-containing T-cell activation inhibitor 1

Gene：VTCN1

Organism：Homo sapiens (Human)

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.（Q7Z7D3）